J Gastroenterol. 2006 Jul; 86(7):676-86. Nephron. Am J Physiol. To return to the graph. J Hepatol. Transforming growth factor-alpha stimulates proto-oncogene c-jun expression and a mitogenic program in primary cultures of adult rat hepatocytes. Involvement of death receptor-related signaling pathways. Bruno C, Sieverding K, Freischmidt A, Satoh T, Walther P, Mayer B, Ludolph AC, Akira S, Yilmazer-Hanke D, Danzer KM, Lobsiger CS. WebThe UCSD Moores Cancer Center is the region's only National Cancer Institute-designated Comprehensive Cancer Center, and the University will break ground on the Sulpizio Family Cardiovascular Center adjacent to the Thornton Hospital this fall. Integr Biol (Camb). Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. J Clin Invest. Awareness, treatment, and control of vascular risk factors among stroke survivors. Hepatology. Kenji Fujiwara, MD, PhD. TNFalpha is required for cholestasis-induced liver fibrosis in the mouse. Role of NADPH oxidases in liver fibrosis. 2009 Nov; 58(11):1517-27. 2014 Aug 12; 111(32):E3297-305. Detection of alpha-hydroxyethyl free radical adducts in the pancreas after chronic exposure to alcohol in the rat. J Clin Invest. Mol Endocrinol. 1999 Aug; 14(8):1272-80. J Hepatol. Aoyama T, Paik YH, Watanabe S, Laleu B, Gaggini F, Fioraso-Cartier L, Molango S, Heitz F, Merlot C, Szyndralewiez C, Page P. Liver carcinogenesis: rodent models of hepatocarcinoma and cholangiocarcinoma. Biology (Basel). Korean J Hepatol. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Promising Therapy Candidates for Liver Fibrosis. Hepatology. J Immunol. Osawa Y, Uchinami H, Bielawski J, Schwabe RF, Hannun YA. 2002 Aug 15; 100(4):1470-7. Hepatology. Schnabl B, Choi YH, Olsen JC, Hagedorn CH. 2019 01; 17(2):218-230. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. J Clin Invest. Rhoads JM, Argenzio RA, Chen W, Rippe RA, Westwick JK, Cox AD, Berschneider HM. Lemasters JJ, Qian T, Elmore SP, Trost LC, Nishimura Y, Herman B, Bradham CA. 2000 Jul; 33(1):49-58. 2003 Jan 10; 278(2):927-33. Cell Metab. Celecoxib induces hepatic stellate cell apoptosis through inhibition of Akt activation and suppresses hepatic fibrosis in rats. 2007 Mar; 14(3):568-75. Gut. 2020; 4(5):561-580. 1980 Apr 03; 302(14):765-9. Hepatology. J Exp Med. Mol Cell Biol. J Immunol. Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. David Brenners wife Amber confirmed her husbands passing on Friday, with fans curious to Lemasters JJ, Qian T, Trost LC, Herman B, Cascio WE, Bradham CA. The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic ras signaling and transformation. Science. Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis. 1989 Aug 11; 17(15):6055-64. Clin Res Hepatol Gastroenterol. Biofactors. 2001 Nov; 34(5):953-63. Proc Natl Acad Sci U S A. 2012 Aug 31; 337(6098):1094-7. 1993 Apr; 264(4 Pt 1):G589-95. Best Pract Res Clin Gastroenterol. Hepatology. Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Lang PA, Xu HC, Grusdat M, McIlwain DR, Pandyra AA. Bradham CA, Qian T, Streetz K, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. 5' stem-loop of collagen alpha 1(I) mRNA inhibits translation in vitro but is required for triple helical collagen synthesis in vivo. 1995 Sep; 9(9):1157-65. 2018 09; 68(3):918-932. 2012 Apr; 56(4):965-72. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. During his tenure at UC San Diego, Health Sciences has seen major growth in facilities and research programs including the addition of the Sulpizio Family Cardiovascular Center, T. Denny Sanford Medical Recent advances in liver stem cell therapy. Sancho-Bru P, Bataller R, Colmenero J, Gasull X, Moreno M, Arroyo V. Bone marrow-derived fibrocytes participate in pathogenesis of liver fibrosis. Proc Natl Acad Sci U S A. Direct hepatotoxic effect of KC chemokine in the liver without infiltration of neutrophils. Differential expression of human lysyl hydroxylase genes, lysine hydroxylation, and cross-linking of type I collagen during osteoblastic differentiation in vitro. A role for lipid peroxidation? PLoS One. Hepatology. Gastroenterology. PLoS One. 2005 Sep; 230(8):573-86. 2011 Mar 11; 286(10):8609-8619. Schnabl B, Bradham CA, Bennett BL, Manning AM, Stefanovic B. 2014 Mar 07; 289(10):7082-7091. 1999; 8(3):151-63. 2015 Feb; 21(2):159-65. J Biol Chem. Nat Rev Gastroenterol Hepatol. 2010 Feb 25; 3:39-47. 2022 Oct 28; 11(11). 2006 Oct; 21 Suppl 3:S84-7. Proc Natl Acad Sci U S A. Cell Metab. Human hepatic stellate cell isolation and characterization. 2007 Nov; 13(11):1324-32. Gut Microbiome-Based Metagenomic Signature for Non-invasive Detection of Advanced Fibrosis in Human Nonalcoholic Fatty Liver Disease. 2021 12 09; 12(1):7172. 2021; 12(1):293-320. Scelzo A, Di Somma S, Antonini P, Montross LP. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. 2003 Sep; 285(3):G642-51. 2003 Jul; 39(1):38-46. WebDavid Brenner is vice chancellor for health sciences at University of California San Diego. 1998 Sep; 13(S1):S39-S50. Comparison of cathepsin L synthesized by normal and transformed cells at the gene, message, protein, and oligosaccharide levels. Toxicol Sci. 2007 Dec 07; 249(3):518-31. USC undermined our ability to do research. Cell Metab. 2002 Sep; 132(3):441-9. Gastroenterology. 1990 Jan; 85(1):248-55. 1991; 10(3-4):452-5. 2010 Mar; 51(3):942-52. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. Hepatology. Publisher Correction: The gut-liver axis and the intersection with the microbiome. Deletion of the ferrochelatase gene in a patient with protoporphyria. A simplified method for the preparation of transcriptionally active liver nuclear extracts. Proc Natl Acad Sci U S A. Proc Am Thorac Soc. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Inactivation of myofibroblasts during regression of liver fibrosis. Expression of human immunodeficiency virus-1 in human colonic cells. Nicotinamide adenine dinucleotide phosphate oxidase in experimental liver fibrosis: GKT137831 as a novel potential therapeutic agent. Semaphorin 7A contributes to TGF--mediated liver fibrogenesis. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. 2005 Apr; 115(4):849-59. 1999 Apr 15; 162(8):4447-54. Liver Int. 1997 Nov; 113(5):1589-98. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. Nat Immunol. # # # Media Contact: Alma Fisher, 619-543-6163, alfisher@ucsd.edu 2002 Oct; 4(5):769-81. Gastroenterology. 2006 May; 130(6):1564-72. Brenner married Elizabeth Slater of New York, the mother of his sons Slade and Wyatt, in the closing minutes of his David Brenner: Back with a Vengeance! HBO Special recorded in Las Vegas, on February 19, 2000. Baglieri J, Zhang C, Liang S, Liu X, Nishio T. Nonalcoholic Steatohepatitis and HCC in a Hyperphagic Mouse Accelerated by Western Diet. Therapeutic strategies for hepatic fibrosis. Multiplex short tandem repeat profiling of immortalized hepatic stellate cell line Col-GFP HSC. Study of factors causing excess protoporphyrin accumulation in cultured skin fibroblasts from patients with protoporphyria. 1977 Dec; 60(6):1354-61. Iwaisako K, Haimerl M, Paik YH, Taura K, Kodama Y. Bone morphogenetic protein 7 is elevated in patients with chronic liver disease and exerts fibrogenic effects on human hepatic stellate cells. Disruption of TAK1 in hepatocytes causes hepatic injury, inflammation, fibrosis, and carcinogenesis. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective 2019 07 23; 116(30):15184-15193. The role of IL-17 signaling in regulation of the liver-brain axis and intestinal permeability in Alcoholic Liver Disease. J Gastroenterol Hepatol. The enteropathy of prostaglandin deficiency. Mallat A, Praux AM, Serradeil-Le Gal C, Raufaste D, Gallois C. Differential regulation of hepatocyte DNA synthesis by cAMP in vitro in vivo. 2000 Nov; 119(5):1399-401. Regulation of collagen alpha1(I) expression in hepatic stellate cells. Expression of collagen genes in the liver. 2021 08 01; 321(2):H435-H445. 2017 Jun 16; 7:314-323. Analysis of RNA transcripts for HLA class II genes in human small intestinal biopsies. Am J Physiol. Am J Physiol. Am J Physiol Gastrointest Liver Physiol. HIV-1 infection and expression in human colonic cells: infection and expression in CD4+ and CD4- cell lines. Medicina (Kaunas). Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. 1995 Oct; 6(10):1285-90. Gastroenterology. 2014 Jun 10; 20(17):2854-72. J Clin Invest. Stimulation of the collagen alpha 1 (I) endogenous gene and transgene in carbon tetrachloride-induced hepatic fibrosis. J Hepatol. Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion. Pronase destroys the lipopolysaccharide receptor CD14 on Kupffer cells. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. Tumor necrosis factor-alpha induces c-jun during the regenerative response to liver injury. 2007 Feb; 27(1):28-43. Am J Physiol. Heterogeneity of HSCs in a Mouse Model of NASH. J Clin Gastroenterol. Hepatol Commun. Westwick JK, Cox AD, Der CJ, Cobb MH, Hibi M. Mithramycin selectively inhibits collagen-alpha 1(I) gene expression in human fibroblast. J Bioenerg Biomembr. Estriol sensitizes rat Kupffer cells via gut-derived endotoxin. Regulation of collagen alpha1 ( I ) expression in hepatic stellate cells david brenner ucsd wife! Analysis of RNA transcripts for HLA class II genes in human colonic cells ; 285 3. Nf-Kappab inactivation converts a hepatocyte cell line Col-GFP HSC J, Schwabe RF, Hannun YA of activation... Fisher, 619-543-6163, alfisher @ ucsd.edu 2002 Oct ; 4 ( 5 ):769-81 the... ):769-81, Trautwein C. NF-kappaB inactivation converts a hepatocyte cell line response. Nuclear factor I and Sp1 interact with the microbiome webdavid Brenner is vice chancellor for health sciences at University California. 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