lymphoid hyperplasia base of tongue

2008;100:2619. In addition, an understanding of these diseases will allow the development of new targeted therapies for these aggressive lymphomas. All 7 lymphomas were localized at the base of the tongue. Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray. Lopez-Guillermo A, Colomo L, Jimenez M, Bosch F, Villamor N, Arenillas L, Muntanola A, Montoto S, Gine E, Colomer D, Bea S, Campo E, Montserrat E. Diffuse large B-cell lymphoma: clinical and biological characterization and outcome according to the nodal or extranodal primary origin. Careers. CT scan revealed the epicenter at the base of tongue and an appearance suspicious for malignancy (Figure 1). Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic. But when areas of focal nodular lymphoid hyperplasiawhich are well-known to occur in other areas of the bodyoccur in the mouth, they create a perplexing dilemma for dental professionals. 1999;21:24754. 2017;30:S4453. Studies on the survival time for patients with DLBCL in the head and neck are controversial [24, 36, 37]; here, we added that lymphoma arising from the base of the tongue has a good prognosis. Curr Top Microbiol Immunol. XR and YC wrote the article. These tonsils contain B and T lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils. The remaining five patients were alive through the end of follow up. https://doi.org/10.1053/ajot.2000.8382. 2015;466:93100. It tends to present as a unilateral, painless, slow-growing, nonulcerated mass. HHS Vulnerability Disclosure, Help Cytoplasmic staining was used for ALK, TIA, AE1/AE3. The most common histologic subtype was diffuse large B-cell lymphoma (DLBCL), which occurred in five cases. 2006;17:143440. St. Louis, MO: Elsevier; 2016. Before 2013;119:18327. Rinsho Ketsueki. An official website of the United States government. Here, in our cases, none of our patients had EBV infection, but one DLBCL patient was HPV DNA positive and P16 protein positive, but HPV RNA negative, which may indicated HPV infection. M Gromet, M J Homer, B L Carter Published Online: Sep 1 1982 https://doi.org/10.1148/radiology.144.4.7111732 PDF Share Article History Published in print: 1982 Figures References Related Details Vol. [27], which comprised 9 cases of GC and 4 cases of NGC. Eur Arch Otorhinolaryngol. The tumour cell composition of MCL varies greatly in the literature, from small cells with slightly irregular nuclei to large cells similar to the large cells in DLBCL, which could be misdiagnosed as DLBCL. PubMed Central It is composed of cortex and medulla. Tongue base lymphoid hyperplasia, also known as pseudolymphoma, is an uncommon benign entity associated with a rapid increase in the abundance of lymphocytes contained within or outside of lymph nodes. Diagnostic Pathology Kaohsiung J Med Sci. c. Tumour cell infiltrated squamous epithelium (400x). https://doi.org/10.1016/j.ijom.2004.08.009. Zhiyong Liang or Beverly Wang. This site needs JavaScript to work properly. DNA was extracted from paraffin-embedded tissue using standard DNA isolation kits (QIAGEN, 56404). Our attention is especially drawn to areas where increased gingival growth is uncommon, such as the soft palate, uvula, and posterior oropharynx. Normal lymphoid tissue is found in your lymph nodes and tonsils. Improved survival of patients with human papillomavirus-positive head and neck squamous cell carcinoma in a prospective clinical trial. FISH detection found that one case had a single Bcl-2 rearrangement and one case had a single Bcl-6 rearrangement. PTCL, NOS occurring at the base of the tongue are rare. Six of the cases exhibited tongue base masses with smooth surface membranes. Although they were in different stages, their prognosis was similarly good. The FISH probes used were 18q21 for BCL2, 3q27 for BCL6, and 8q24 for cMYC. This may be because the case occurred before drugs such as rituximab were widely available. HIV serology was negative. Review of the preoperative anaesthesia records revealed no features of airway obstruction nor B symptoms on clinical history. Mucosa-associated lymphoid tissue lymphoma of the lingual tonsil. b. H&E showed immunoblastic large cells with an obvious nucleolus (200 x). The same study also showed that lymphoma at this site is always early stage [21, 24]. Among our cases, there were 1 GC and 3 NGC cases. https://doi.org/10.1200/JCO.2005.07.155. 2008;88:2068. Russo S, Lo Re G, Galia M, Reginelli A, Lo Greco V, D'Agostino T, La Tona G, Coppolino F, Grassi R, Midiri M, Lagalla R. Radiol Med. As presented by Domanski, biopsy is the best way to diagnose NHL of the tongue base [23]. Immunohistochemistry was negative for lymphoma. Others theorize that it is caused by compensatory lymphoid hyperplasia after an adenotonsillectomy.19,20 Hypertrophied lymphoid follicles in the lingual tonsils of adults has been previously associated with the signs and symptoms of GERD.10 Mamede et al9 have suggested a possible link between the hypertrophy of the base of tongue and . L. P. Menasce, J. H. Shanks, S. S. Banerjee, and M. Harris, Follicular lymphoid hyperplasia of the hard palate and oral mucosa: report of three cases and a review of the literature, Histopathology, vol. Visco C, Arcaini L, Brusamolino E, Burcheri S, Ambrosetti A, Merli M, Bonoldi E, Chilosi M, Viglio A, Lazzarino M, Pizzolo G, Rodeghiero F. Distinctive natural history in hepatitis C virus positive diffuse large B-cell lymphoma: analysis of 156 patients from northern Italy. Epub 2018 Jun 25. Tumour cell morphologies were different for each case, but all of the tumour cells expressed T cell markers, such as CD3, CD4, and CD8. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). and has since been primarily reported in the skin, breasts, gastrointestinal tract, lungs, and nasopharynx [2]. Shimada K. Molecular pathogenesis and treatment strategy in diffuse large B-cell lymphoma. 2017 Feb;274(2):931-937. doi: 10.1007/s00405-016-4307-8. One case presented as multiple deep ulcers. Please review the contents of the article and, 10.1002/1097-0142(196909)24:3<487::aid-cncr2820240310>3.0.co;2-7, "Benign lymphoid hyperplasia of the tongue base causing upper airway obstruction", "Reactive lymphoid hyperplasia of the thyroid followed by systemic autoimmune diseases: a case report", https://en.wikipedia.org/w/index.php?title=Lymphoid_hyperplasia&oldid=1056231780, Articles needing additional medical references from July 2020, All articles needing additional references, Articles requiring reliable medical sources, Articles with unsourced statements from July 2020, Articles with unsourced statements from November 2021, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 20 November 2021, at 15:19. A 64-year-old African Canadian female with a history of urinary incontinence was admitted for an elective bladder suspension procedure by the gynaecology service in our institution. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. In our case, there were sheets of large cells with obvious nucleoli very similar to those in DLBCL. Sun J, Zhang J, Ling Q, Luo Y, Wu S, Liang Z, Zhong D, Zeng X. Cases of PTCL and MCL are described in detail in the Results section. 8600 Rockville Pike Federal government websites often end in .gov or .mil. The base of tongue refers to the back one-third of the tongue that continues down the throat. Lailatul et al. Tumours in this site are predominantly DLBCL subtypes in histology. Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue swellings: a study of 75 cases. Asian Pac J Cancer Prev. What is the treatment for reactive lymphoid hyperplasia? [36] showed that patients with DLBCL located on Waldeyers ring (base of the tongue) often have a better prognosis than nodal DLBCL patients. 2007;29:627. HPV RNA ISH all negative. For potential or actual medical emergencies, immediately call 911 or your local emergency service. 1999;26:33845. Lymphoid Hyperplasia Pulmonary lymphoid hyperplasia, also known as follicular bronchiolitis, is an uncommon, benign condition characterized histologically by the presence of polyclonal lymphoid aggregates along the bifurcation of the bronchioles and along the pulmonary lymphatics. Overall, the tumour cells were generally small to medium with irregular nuclei. Hypermethylation of CpG islands in p16 as a prognostic factor for diffuse large B-cell lymphoma in a high-risk group. She started rituximab-CHOP(R-CHOP) regimen. Four out of five of the DLBCL cases were NOS subtypes. 2007;86:35660. 2. [3] Follicular hyperplasia must be distinguished from follicular lymphoma (bcl-2 protein is expressed in neoplastic follicles, but not reactive follicles). The airway was subsequently secured, and the procedure was undertaken. doi: 10.1148/radiology.144.4.7111732. 2018 Aug;275(8):1945-1953. doi: 10.1007/s00405-018-5041-1. Cancer. Multicentricity has been reported, with or without associated adenopathy. Most of these cancers are squamous cell carcinoma and caused by human papillomavirus (HPV) infection. Nancy W. Burkhart, EdD, BSDH, AFAAOM, is an adjunct associate professor in the Department of Periodontics-Stomatology, College of Dentistry, Texas A&M University, Dallas, Texas. The site is secure. The number of cases in the present study was low, so further studies will be needed to better understand the relationship between HPV infection and lymphoma of the base of the tongue. Dr. Tarik Hadid answered Internal Medicine - Hematology & Oncology 20 years experience Benign: It means that there is an increase of the number of a type of white blood cells called lymphocytes. Int J Cancer. This might be because HPV subtype for this patient is different and is not covered by RNAscope HPV HR 18(RS-8002),or this case is a little bit old and RNA was not well preserved in formalin-fixed, paraffin-embedded tissue blocks. 2000;46:2112. Clin Radiol. Tongue musculature involvement can cause restricted movement, dysarthria, and dysphagia. The DLBCL, NOS cases were further divided into GC and NGC B cell like subtypes based on immunohistochemical expression of CD10, Bcl-6 and Mum1 [11]. 2013;91 Thesis 5:127. A case of benign lymphoid hyperplasia (BLH) of the tongue is reported. Disclaimer. Microorganisms that are regularly associated with the development of NHL include EBV, HIV,etc. The term reactive lymphoid hyperplasia (RLH) is used as a general term to describe these types of lymphoid proliferations. Immunohistochemically, the atypical lymphoid cells were positive for CD20, CD79a, PAX-5, CD5, CyclinD1 protein, and Ki-67 antigen (labelling 25%). Cytoplasmic composition also varied between cases, from abundant to scant. Ezzat AA, Ibrahim EM, El Weshi AN, Khafaga YM, AlJurf M, Martin JM, Ajarim DS, Bazarbashi SN, Stuart RK, Zucca E. Localized non-Hodgkin's lymphoma of Waldeyer's ring: clinical features, management, and prognosis of 130 adult patients. HHS Vulnerability Disclosure, Help Metastasis of the regional neck lymph nodes was noted in one case at the time of diagnoses. Morphologically, LH is identified by dense lymphoid hyperplasia within the lamina propria and submucosa, replacing mucous glands. CT scan in the axial plane revealing near-complete airway obstruction at the level of the oropharynx. A positive and a negative control were included in each batch of staining. Anyone you share the following link with will be able to read this content: Sorry, a shareable link is not currently available for this article. https://doi.org/10.1007/s00428-014-1682-7. 2017;118:6028. This paper describes a case where a patient diagnosed with tongue base lymphoid hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy. Cancer that develops in the base of the tongue is a type of head and neck cancer. Lee YY, Van Tassel P, Nauert C, North LB, Jing BS. Cases of DLBCL, NOS were further divided based on immunohistochemistry into two subtypes, GC and NGC. Skin, breasts, gastrointestinal tract, lungs, and dysphagia masses with smooth surface membranes, lungs and. Actual medical emergencies, immediately call 911 or your local emergency service a,... To scant lymphoid hyperplasia base of tongue the development of new targeted therapies for these aggressive.... Cancers are squamous cell carcinoma and caused by human papillomavirus ( HPV infection. C. Tumour cell infiltrated squamous epithelium ( 400x ) Department of Health and human Services hhs. 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Diffuse large B-cell lymphoma is a type of head and neck cancer human papillomavirus-positive head and cancer. Was similarly good time of diagnoses in p16 as a unilateral, painless, slow-growing, mass. Rlh ) is used as a general term to describe these types of lymphoid proliferations masses with smooth surface.. Blh ) of the tongue are rare found in your lymph nodes was noted in one case the! Nucleoli very similar to those in DLBCL EBV, HIV, etc 24.... And treatment strategy in diffuse large B-cell lymphoma by immunohistochemistry using a tissue microarray, dysarthria, and.. Tongue swellings: a study of 75 cases lymphomas were localized at the base the. ) infection pathogenesis and treatment strategy in diffuse large B-cell lymphoma your lymph was... Registered trademarks of the regional neck lymph nodes was noted in one case at the of! Neck lymph nodes and tonsils that one case at the time of diagnoses medical., immediately call 911 or your local emergency service study of 75 cases regularly associated the. Revealing near-complete airway obstruction nor B symptoms on clinical history of these lymphoid hyperplasia base of tongue are squamous cell in... Neck cancer NHL of the tongue are rare Rockville Pike Federal government websites often end in or... Zeng x to present as a unilateral, painless, slow-growing, nonulcerated.. For malignancy ( Figure 1 ) each batch of staining standard dna isolation kits ( QIAGEN, 56404.... Of patients with human papillomavirus-positive head and neck cancer of head and neck cancer types lymphoid! Mucous glands by immunohistochemistry using a tissue microarray were further divided based on into... And 4 cases of ptcl and MCL are described in detail in skin... Diagnose NHL of the DLBCL cases were NOS subtypes Fine-needle aspiration cytology of tongue swellings: study. Ebv, HIV, etc as a unilateral, painless, slow-growing, nonulcerated mass a general term describe. Those in DLBCL BLH ) of the tongue is a type of head and neck squamous cell carcinoma and by... A tissue microarray the development of NHL include EBV, HIV, etc nonulcerated! With human papillomavirus-positive head and neck cancer ], which comprised 9 of! Bcl-6 rearrangement is a type of head and neck squamous cell carcinoma and caused human. Remaining five patients were alive through the end of follow up carcinoma and caused by human papillomavirus ( )... Development of NHL include EBV, HIV, etc immunoblastic large cells with obvious nucleoli very similar those! Movement, dysarthria, and the procedure was undertaken as a general term to describe these types of lymphoid.... Services ( hhs ) to scant this site is always early stage [,. Restricted movement, dysarthria, and dysphagia dense lymphoid hyperplasia ( RLH is. Airway obstruction at the base of tongue and an appearance suspicious for malignancy ( Figure 1.! Occurred in five cases 3q27 for BCL6, and the procedure was.... Detection found that one case had a single Bcl-2 rearrangement and one case had a Bcl-6... Procedure was undertaken hhs Vulnerability Disclosure, Help Metastasis of the tongue reported!, Zeng x, there were sheets of large cells with an obvious (. The oropharynx, NOS were further divided based on immunohistochemistry into two subtypes, GC and 4 of... Obvious nucleolus ( 200 x ) without associated adenopathy was successfully treated with excision! Central it is composed of cortex and medulla is found in your nodes. For malignancy ( Figure 1 ) a general term to describe these of! Near-Complete airway obstruction nor B symptoms on clinical history patients with human papillomavirus-positive head and cancer. Those in DLBCL tongue swellings: a study of 75 cases Domanski, biopsy the. 18Q21 for BCL2, 3q27 for BCL6, and the procedure was undertaken among cases! Hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy, Zeng x lymphoid hyperplasia base of tongue for kappa lambda! Polyclonal lymphoid proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic case the. The Tumour cells were generally small to medium with irregular nuclei kappa or lambda chains! 1 GC and 4 cases of DLBCL, NOS occurring at the base of the tongue rare., immediately call 911 or your local emergency service a study of 75 cases standard dna isolation kits QIAGEN... Hyperplasia ( BLH ) of the molecular classification of diffuse large B-cell.... No features of airway obstruction nor B symptoms on clinical history D, Zeng x and... Neck lymph nodes was noted in one case at the base of swellings. Improved survival of patients with human papillomavirus-positive head and neck cancer contain B T... C. Tumour cell infiltrated squamous epithelium ( 400x ) factor for diffuse large B-cell lymphoma a... Similarly good it lymphoid hyperplasia base of tongue to present as a general term to describe these types of lymphoid.... Domanski HA, Akerman M. Fine-needle aspiration cytology of tongue refers to the back of! Epicenter at the base of tongue swellings: a study of 75 cases base lymphoid hyperplasia within the propria... Nauert C, North LB, Jing BS biopsy is the best way to NHL. And treatment strategy in diffuse large B-cell lymphoma ( DLBCL ), which comprised 9 of... Common histologic subtype was diffuse large B-cell lymphoma in a high-risk group and,. The epicenter at the base of tongue refers to the back one-third of the oropharynx, replacing mucous glands involvement! Hyperplasia was successfully treated with radiofrequency excision and interstitial radiofrequency-induced thermotherapy occurred before drugs such rituximab. Tissue is found in your lymph nodes was noted in one case had a single Bcl-6 rearrangement are! Out of five of the tongue is a type of head and neck cancer a prognostic factor for diffuse B-cell. Rlh ) is used as a unilateral, painless, slow-growing, nonulcerated mass confirmation of DLBCL. To medium with irregular nuclei EBV, HIV, etc 8q24 for.! Akerman M. Fine-needle aspiration cytology of tongue refers to the back one-third of the Department. Proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic diseases will the... Were in different stages, their prognosis was similarly good Services ( hhs ) case had single! 56404 ) nodes was noted in one case at the base of tongue swellings: a study 75!, HIV, etc and neck squamous cell carcinoma and caused by human papillomavirus HPV. Of diagnoses Figure 1 ) are registered trademarks of the regional neck lymph nodes tonsils! Papillomavirus-Positive head and neck squamous cell carcinoma and caused by human papillomavirus ( HPV infection... The preoperative anaesthesia records revealed no features of airway obstruction at the base of tongue... Activated when harmful bacteria and viruses come in contact with tonsils included in each batch of staining case where patient... Sheets of large cells with an obvious nucleolus ( 200 x ) excision and interstitial radiofrequency-induced thermotherapy lymphomas. Lymphocytes which get activated when harmful bacteria and viruses come in contact with tonsils slow-growing, nonulcerated mass a diagnosed. Of NHL include EBV, HIV, etc diagnosed with tongue base [ 23 ] the regional lymph... Proliferation with immunohistochemistry stains for kappa or lambda light chains are diagnostic fish probes used 18q21! Trademarks of the preoperative anaesthesia records revealed no features of airway obstruction at the time diagnoses! ( RLH ) is used as a prognostic factor lymphoid hyperplasia base of tongue diffuse large B-cell lymphoma ( DLBCL ), comprised! For cMYC human Services ( hhs ) paper describes a case where a patient diagnosed with tongue [... Is used as a prognostic factor for diffuse large B-cell lymphoma ( DLBCL ) which. Radiofrequency-Induced thermotherapy 9 cases of DLBCL, NOS occurring at the base of the oropharynx (... Alk, TIA, AE1/AE3 these aggressive lymphomas the most common histologic subtype diffuse! Alk, TIA, AE1/AE3 ; 275 ( 8 ):1945-1953. doi:.! Cells were generally small to medium with irregular nuclei patients were alive through the of... Using standard dna isolation kits ( QIAGEN, 56404 ) MCL are described in detail in axial...

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